#  Unique model identifier
Model_code     B

# Model description 
Description  Two-site, positive cooperativity due to the interaction between neighboring sites, same signs of binding and interaction enthalpies

# Association constants
Ka_names    A1a       A1b        A2a   
Ka          1e5       1.05e5        1e7

# Rate constants of REVERSE reactions
k_names       A1a      A1b       A2a        A2b 
k2            1        1       1        1 

# Names of NMR-active species
Species_names      R     LaR      RLb     RL2   

# Names of NMR unobservable species
NMR_invisible_species_names     L  

# Chemical shifts of pure species, 1/s
w0        0       100    200     300 

# Relaxation rates of pure species, 1/s
R2      10      10      10       10      

# Heat of formation of the species, relative units
# The original species is a standard state with dH=0 !
# Here I assume negative heat of binding for the first ligand
# and larger heat of binding of the second ligand (due to interaction
# with the previously occupied site with additional negative enthalpy)
# (making dH(RL2) > 2*dH(RL)) 
dH     0       -1         -1        -2.5